• Home
  • Browse
    • Current Issue
    • By Issue
    • By Author
    • By Subject
    • Author Index
    • Keyword Index
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Publication Ethics
    • Peer Review Process
  • Guide for Authors
  • Submit Manuscript
  • Reviewers
  • Contact Us
 
  • Login
  • Register
Home Articles List Article Information
  • Save Records
  • |
  • Printable Version
  • |
  • Recommend
  • |
  • How to cite Export to
    RIS EndNote BibTeX APA MLA Harvard Vancouver
  • |
  • Share Share
    CiteULike Mendeley Facebook Google LinkedIn Twitter
The Medical Journal of Cairo University
arrow Articles in Press
arrow Current Issue
Journal Archive
Volume Volume 90 (2022)
Volume Volume 89 (2021)
Volume Volume 88 (2020)
Issue December
Issue September
Issue June
Issue March
Volume Volume 87 (2019)
Volume Volume 86 (2018)
AHMED S. ABDELSHAFY, M.D., A., ALMABROUK, M.Sc., M. (2020). Topical Finasteride versus Topical Spironolactone in the Treatment of Androgenetic Alopecia. The Medical Journal of Cairo University, 88(June), 1017-1022. doi: 10.21608/mjcu.2020.110836
AYMAN E. YOUSEF, M.D.; AHMED S. ABDELSHAFY, M.D.; MOUSA A.S. ALMABROUK, M.Sc.. "Topical Finasteride versus Topical Spironolactone in the Treatment of Androgenetic Alopecia". The Medical Journal of Cairo University, 88, June, 2020, 1017-1022. doi: 10.21608/mjcu.2020.110836
AHMED S. ABDELSHAFY, M.D., A., ALMABROUK, M.Sc., M. (2020). 'Topical Finasteride versus Topical Spironolactone in the Treatment of Androgenetic Alopecia', The Medical Journal of Cairo University, 88(June), pp. 1017-1022. doi: 10.21608/mjcu.2020.110836
AHMED S. ABDELSHAFY, M.D., A., ALMABROUK, M.Sc., M. Topical Finasteride versus Topical Spironolactone in the Treatment of Androgenetic Alopecia. The Medical Journal of Cairo University, 2020; 88(June): 1017-1022. doi: 10.21608/mjcu.2020.110836

Topical Finasteride versus Topical Spironolactone in the Treatment of Androgenetic Alopecia

Article 5, Volume 88, June, June 2020, Page 1017-1022  XML PDF (396.55 K)
Document Type: Original Article
DOI: 10.21608/mjcu.2020.110836
Authors
AYMAN E. YOUSEF, M.D.; AHMED S. ABDELSHAFY, M.D.; MOUSA A.S. ALMABROUK, M.Sc.
The Department of Dermatology and Venereology, Faculty of Medicine, Zagazig University, Egypt* and Tripoli University, Libya**
Abstract
Abstract Background: Androgenetic Alopecia (AGA) is a non-scarring alopecia that affects both males and females. It is characterized by a progressive miniaturization of hair follicles with a characteristic pattern distribution in genetically predis-posed men and women. Topical finasteride is being investigated as a new treatment for AGA with fewer side effects than oral finasteride. Topical Spironolactone is the most commonly used off-label anti-androgen for the treatment of AGA. In the treatment of AGA, it acts by decreasing the production and competitively blocking the androgen receptor in the target tissue. Aim of Study: The aim of this study was to evaluate the role and compare the effect of topical finasteride and topical spironolactone in the treatment of (AGA). Patients and Methods: After meeting inclusion and ex-clusion criteria and diagnosis of AGA was clinically established by the characteristic distribution of frontal and vertex hair in males and the Christmas tree pattern of diffuse hair loss at middle hairline in females. It was dermosopically established by the characteristic hair shaft thickness heterogeneity, peripilar brown depressions (peripilar signs) and focal atrichia and also folliscope established for hair density. Cases included in this study had Norwad-Hamilton Scale types I to VII for men and Ebling Scale types I to IV for women. Result: Our study shows that a topical spironolactone is better than topical finasteride in male and female group. Conclusion: In this study, topical finasteride and topical spironolactone are good options for management of androgenic alopecia but topical spironolactone is better than topical finasteride with few side effects when compared to oral administration.
Keywords
Alopecia; Finasteride; Spironolactone
Statistics
Article View: 1,080
PDF Download: 6,829
Home | Glossary | News | Aims and Scope | Sitemap
Top Top

Journal Management System. Designed by NotionWave.