Evaluation of Cardiac Troponin I as a Predictor of Outcome ofSepsis in Critically Ill Patients

AbstractBackground: Sepsis and septic shock are the most commoncauses of morbidity and mortality in Intensive Care Units inthe United States. The cardiovascular abnormalities associatedwith septic shock, in large part, account for the life-threateningnature of the syndrome. Cardiac troponin I (cTnI) has beenshown to be an indicator of myocardial injury and is anaccepted prognostic factor of Myocardial Infarction (MI).Aim of Study: To study the prognostic value of cTnI onmortality and adverse complications in patients with sepsisand septic shock. And to study the relation of cTnI with ICUscoring system (SOFA).Patients and Methods: This is a comparative cross sec-tional study, was conducted at Intensive Care Unit (ICU) atAin Shams University Hospitals and El-Matria TeachingHospital, on 70 patients with suspected infection who wereaged between 18 and 60 years old, over the period of sixmonths from November 2019 to April 2020.Results: Finally, as regard relation between outcome and1st sample cTnI in each group; the study on the hand revealedthat there was no statistical significant difference betweenoutcome and 1st sample cTnI in Group with positive cTnI,Group II with non-elevated cardiac troponin I.Conclusion: Based on our results we recommend forfurther studies in larger patients and longer period of follow-up to emphasize our conclusion. Sepsis patients with highcTnI levels are usually more critically ill while had the samechance to adverse outcome and less mortality and cTnI level is not a predicator of mortality, further studies in larger patient populations must establish whether elevated troponin may be used as an independent mortality risk factor for intensive care patients without ACS.