Role of Preoperative DWI-MRI and Dynamic Contrast Enhanced MRI in Predicting Aggressive Disease in Endometrial Carcinoma

BASANT M. RAIEF MOSAAD, M.D., SHERINE K. AMIN, M.D.;; E. MAHFOUZ ALI, M.Sc., HEBATULLAH

doi:10.21608/mjcu.2021.225166

Role of Preoperative DWI-MRI and Dynamic Contrast Enhanced MRI in Predicting Aggressive Disease in Endometrial Carcinoma

Authors

The Department of Radiology, Faculty of Medicine, Ain Shams University

10.21608/mjcu.2021.225166

Abstract

Abstract Background: Endometrial cancer is the most common gynecologic cancer seen in women today, It is more prevalent in high-resource countries, but its incidence is rising in low-resource countries as a result of rising obesity and improved longevity. Aim of Study: The purpose of this study is to evaluate the accuracy of DWI and dynamic contrast enhanced MRI in preoperative staging of endometrial carcinoma and prediction of severity of the disease prior to surgery. Patients and Methods: The study included 20 patients referred from the Gynecology Department to the Radiology Department in Ain Shams University Hospitals from October 2020 to July 2021. They were all presented with postmeno-pausal bleeding or menorrhagia. Results: The current study showed that as regard MRI signal characteristics in the studied group; 45% were isointense in relation to myometrium on T2WI. 100% revealed high signal intensity (restricted diffusion) on DWI. 100% had ADC value <1.2 x 10-3mm2/s. There was no significant association between histological grade of endometrial carcinoma and the ADC value of each grade. There was highly significant difference between MRI Staging and Surgical Staging. There was no significant difference between MRI findings and Surgical Findings. Conclusion: DCE-MRI and DWI represent valuable sup-plements to conventional MRI by providing preoperative imaging biomarkers that predict aggressive disease in endome-trial cancer patients.

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