Slug, CD44 and Her-2/neu Immunohistochemical Expression in Gastric Carcinoma


The Department of of Pathology, Faculty of Medicine, Al-Azhar University


Abstract Background: The major prognostic factors in carcinoma of the stomach are the depth of invasion into the gastric wall and the degree of differentiation of the tumor. However, there is no reliable parameter predicting the risk of recurrence or progression. Molecular markers are, therefore, required to estimate the individual prognosis of patients as well as for effective treatment. Aim of Study: To evaluate the immunohistochemical expression of Sulg, CD44 and Her-2/neu in gastric carcinoma and to correlate slug and CD44 expression as prognostic markers with available clinicopathologic features, correlate Her-2/neu as predictive marker with clinicopathologic features and to correlate the relation between slug, CD44 and Her-2/neu expressions. Material and Methods: Slug, CD44 and Her-2/Neu were assessed by immunohistochemistry in 50 specimens of gastric carcinoma, collected from Al-Azhar Faculty of Medicine Hospital labs and some private labs, within the period from November 2017 to February 2021. All specimens were obtained through gastrectomy. Results: There were statistically significant relations between Slug and CD44 immunohistochemical expressions in gastric carcinomas, and distal tumor locations, high pT stage and high pN stage. And there was significantly relation between Her-2/neu expression and proximal tumor location, histopathological type/grade and advanced pT stage. Conclusion: Slug, CD44 and Her-2 / neuimmunohisto-chemical expressions were directly related to stage of gastric carcinomas and could be of valuable significance in predicting the aggressive invasive gastric tumors and subsequently the need to aggressive treatment options.