Serum Soluble CD163 as a Marker of Activity in MS Patients

Document Type : Original Article

Authors

The Department of Clinical Pathology, Faculty of Medicine, Ain Shams University

Abstract

Abstract Background: Multiple sclerosis (MS) is a chronic autoim-mune disease that affects the central nervous system. Microglia and macrophages have a substantial role in myelin and axonal degeneration by causing neuro-inflammatory damage. Soluble CD 163 one of the myeloid linage biomarkers, showed a better correlation with monocyte count in the CSF of MS patients. Aim of Study: In the current case control observational study, we aimed to assess serum level of sCD163 as an immunological non-invasive marker for MS activity. Patients and Methods: Sixty relapsing remitting multiple sclerosis (RRMS) patients were included and divided into 2 groups based on disease activity. Twenty-eight matched healthy controls were included and all subjects' serum levels of sCD163 were measured using ELISA. Results: This study demonstrated a highly significant-difference between the whole patients compared to controls with a concomitantno statistically significant difference between the patients' groups. Conclusion: This study emphasized the relevance of serum level of sCD 163 as a non-invasive immunological biomarker in the diagnostic panel of MS reflecting the inflammatory process rather than the activity status of the patients.

Keywords

The Medical Journal of Cairo University
Volume 90, Issue 6
June 2022
Pages 1039-1045

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