The Effect of Statins on the Patency Rate of Peripheral Vessels after Balloon Angioplasty

SHERIF OMAR EL KERDAWI, M.D., ALI MAHMOUD MOHAMED GALAL, M.D.; ESMAIL SERAGELDIN, M.D., AHMED M. ABD EL RAHIM, M.Sc.;

doi:10.21608/mjcu.2022.272094

The Effect of Statins on the Patency Rate of Peripheral Vessels after Balloon Angioplasty

Document Type : Original Article

Authors

The Department of Vascular Surgery, Faculty of Medicine, Aswan1, Helwan2 Universities, Plymouth University Hospitals NHS Trust, UK3 and Vascular Surgery Department, Shebin Elkom Teaching Hospital4, Egypt

10.21608/mjcu.2022.272094

Abstract

Abstract Background: Statins (hydroxymethylglutaryl-coenzyme A reductase inhibitors) have long been recognized to substan-tially decrease cardiovascular events in people with peripheral vascular dysfunction. Aim of Study: The aim of the research was to assess the effect of routine use of statins after plain balloon angioplasty of infrainguinal vessels to increase the patency rate. Patients and Methods: This was a randomized controlled research to assess the effect of routine normal utilization of statins after plain balloon angioplasty of infrainguinal vessels to increase the patency rate. We included 270 patients with infrainguinal POBA. We blindly randomized the patients into 2 groups, first with routine postoperative statins use (150). The second groups without postoperative statins use (120). We exclude all patients who have used drug coated balloons. Results: ABI in group I was much lower than in group II, whereas technical success was substantially better in group I than in group II. However, there is no discernible difference in terms of complications or length of stay in the hospital. 12-months and 24-months patency was substantially greater in group I compared to group II. Conclusions: Statins are of great importance in improving cardiovascular protection, inhibiting the progression of PAD, and improving clinical outcomes after interventional therapy in PAD.

Keywords