Correlation between Glycated Hemoglobin (HBA1c), Glycated Albumin Levels and Cardiovascular Risk Factors in Pre-Diabetic Metabolic Syndrome Patients..

Abstract Background: The metabolic syndrome is a major and esca-lating public-health problem. It is a predisposing factor of car-diovascular disease .Cardiovascular disease is a leading cause of morbidity and mortality all over the world. Studies have shown that subjects having pre-diabetes are also at a high risk for CVD. Pre-diabetesrefers to an intermediatestage between normal glucose toleranceand overt T2DM, Glycated albumin reflects short-term (2-3 weeks) mean glycemic levels. GA val-ues, unlike HbAlc, are not affected by changes in erythrocyte lifespan. Aim of Study: The aim of the study is to correlate between HbAlc, glycated albumin and cardiovascular risk factors in prediabetic metabolic syndrome patients. Patients and Methods: One hundred pre-diabetic patients diagnosed as metabolic syndrome were subjected to full histo-ry taking and examination, full anthropometric measurements, laboratory tests including: FBS, uric acid, HbAlc, lipid profile, glycated albumin levels, urea, creatinine and A/c ratio. Results:Our study showed that anthropometric measures including weight, waist circumference, neck circumference, hip circumference, triceps thicknesswere all negatively corre-lated to glycated albuminwith p-values (<0.001, 0.003, <0.001, 0.007, 0.014) respectively. On the other hand weight, waist circumference, neck circumference and subscapular skin fold thickness were positively correlated to HbAlc level with p-val-ues (<0.001, 0.01, 0.016 and 0.009) respectively. Regarding metabolic syndrome and cardiovascular risk factors, Triglyceride levels are negatively correlated to HbAlc levels (p-value 0.01). LDL levels are positively correlated to HbAlc levels (p-value 0.02). BMI is negatively correlated to glycated albumin level (p-value <0.001) but positively correlat-ed to HbAlc level (p-value <0.001). As for pre-diabetes, fasting blood sugar is positively correlated to glycated albumin levels (p-value 0.002) with no statistical correlation to HbAlc levels. Conclusion: Both glycated albumin and HBA1c are cor-related to anthropometric measures hence their importance in assessment of obesity. HbAlc is more correlated to metabolic syndrome and cardiovascular risk factors than glycated albu-min. Glycated albumin showed positive correlation to FBG, thus can be used for diagnosis of pre-diabetes especially when combined with HbAlc.