Study of Gut Klebseilla in Biliary Atresia

SAMAH M. AWAD, M.D.** And MONA A. SEIF EL DEEN, M.Sc.***, MOHAMMED A. EL-GUINDI, M.D.*; ALIF A. ALLAM, M.D.*; OLA A. FOUAD, M.D.*;

doi:10.21608/mjcu.2024.411333

Study of Gut Klebseilla in Biliary Atresia

Document Type : Original Article

Author

MOHAMMED A. EL-GUINDI, M.D.*; ALIF A. ALLAM, M.D.*; OLA A. FOUAD, M.D.*; SAMAH M. AWAD, M.D.** and MONA A. SEIF EL DEEN, M.Sc.***

The Department of Pediatric Hepatology, Gastroenterology, and Nutrition*, National Liver Institute, Menoufia University, Department of Medical Microbiology and Immunology**, National Liver Institute, Menoufia University and Pediatric Department, Damanhour Health Administration, Beheira Governorate***, Ministery of Health and Population

10.21608/mjcu.2024.411333

Abstract

Abstract Background: Biliary atresia (BA) is a neonatal cholestasis disease that is characterized by fibrosclerosing and inflammato-ry obliteration of the biliary tracts, which leads to progressive liver damage. It is the most common cause of cholestasis in the first 3 months of life presented by progressive conjugated jaundice, pale acholic stools and dark with later ones being, as-cites, portal hypertension and splenomegaly. The recommend-ed treatment is kasai portoenterostomy & liver transplantation. Characterization of gut klebsiella profile in infants with biliary atresia can provide valuable information and potential disease biomarkers. Aim of Study: Our study aims to characterize the gut Kleb-siellain infants with biliary atresia. Material and Methods: This study was a case control study that included 10 infants diagnosed as BA&10 age-matched healthy infants as a control group. Results: Increase level of Klebsiellain BA group more than control group. There was significant difference between BA group & control group (p-value >0.05). Conclusion: Increased level of gut Klebsiella is associated with the incidence of biliary atresia.

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