Serum Vitamin D Level in Patients with Knee Osteoarthritis: Relationship to Clinical and Radiological Severity

SABRIN M.A. MANDOR, M.Sc.*, HISHAM M. HABIB, M.D.*; EMAN A. HAFEZ, M.D.*; MAYADA A. GHANNAM, M.D.**

doi:10.21608/mjcu.2025.464475

Serum Vitamin D Level in Patients with Knee Osteoarthritis: Relationship to Clinical and Radiological Severity

Document Type : Original Article

Author

HISHAM M. HABIB, M.D.*; EMAN A. HAFEZ, M.D.*; MAYADA A. GHANNAM, M.D.** SABRIN M.A. MANDOR, M.Sc.*

The Department of Physical Medicine, Rheumatology & Rehabilitation* and Clinical Pathology (Haematology)**, Faculty of Medicine, Mansoura University

10.21608/mjcu.2025.464475

Abstract

Background: Osteoarthritis (OA) is a common joint condi-tion that typically causes chronic pain. OA has been associated with degenerative changes. Vitamin D deficiency might be as-sociated with OA and therefore warrants routine screening of such patients. Aim of Study: To identify serum level of vitamin D in pa-tient with primary Knee OA (KOA) in comparison with normal control group and to evaluate the association between the level of vitamin D and the clinical severity and the radiological se-verity. Material and Methods: Case control study, carried on 90 individuals, 45 cases (patients having knee OA) and 45 healthy control, and vitamin D level was assessed by ELIZA in both groups. Results: Cases with OA had statistically significant low-er levels of vitamin D compared to control group. The mean serum vitamin D among cases is 20.94±9.23ng/ml versus 32.72±12.56 among control group. Vitamin D had moderate discriminating ability for differentiation between OA cases and healthy group. Conclusion: There was significant negative correlation be-tween vitamin D level and clinical and radiological severities of KOA patients.

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