Radiation Induced Liver Damage in Patients with Liver Cancer

Document Type : Original Article

Authors

1 The Departments of Clinical Oncology* and Physics Radiation Oncology, Faculty of Medicine, Cairo University

2 The Departments of Clinical Oncology* and Physics Radiation Oncology**, Faculty of Medicine, Cairo University

Abstract

Abstract
Background: Assessment of toxicity of radiation therapy and factors that influence the occurance of toxicity in patients with inoperable Hepatocellular carcinoma
Aim of Work: To evaluate the safety of radiation therapy using volumetric modulated arc therapy in patients with inoperable Hepatocellular carcinoma.
Patients and Methods: Between May 2014 and April 2016, twenty five patients with inoperable Hepatocellular carcinoma and not amenable to local ablative therapies received radiation therapy using VMAT 50.4 Gy in 28 fractions. We evaluated clinical as well as dosimetric factors related to the occurrence of RILD.
Results: RILD occurred in 28% of the patients and the mean volume of PTV was the only factor causing statistically significant difference in the occurrence of RILD with a mean PTV volume of 620.2cc in the RILD group versus 579.7cc in the No RILD group with a p=0.028
Conclusion: Lowering PTV volume contributes in the prevention of occurrence of RILD.

Keywords

The Medical Journal of Cairo University
Volume 87, March
March 2019
Pages 13-18

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