Thiamine Supplementation is Beneficial as Adjunctive Therapy to ACE Inhibitors to Improve the Course of Nephrogenic Complications of Type II Diabetes Mellitus: Possible Involvement of the Inflammatory Cascade as a Mechanism of this Effect

AKEF A. KHOWAILED, M.D., MOHAMED M. KHALIFA, M.D.;; HANAN FOUAD, M.D., MINA J. AYAD, M.Sc.;; R.M. EL-ANSARI, M.D., MAHMOUD

doi:10.21608/mjcu.2019.53295

Thiamine Supplementation is Beneficial as Adjunctive Therapy to ACE Inhibitors to Improve the Course of Nephrogenic Complications of Type II Diabetes Mellitus: Possible Involvement of the Inflammatory Cascade as a Mechanism of this Effect

Document Type : Original Article

Authors

10.21608/mjcu.2019.53295

Abstract

Abstract
Background: Diabetic nephropathy is one of the most common complications of type II diabetes mellitus. Different recent researches investigated the therapeutic effects of different medications and therapeutic agents on the progression of diabetic nephropathy.
Aim of Study: Compare the reno-protective effects of thiamine in addition to ACE inhibitors in type 2 diabetic kidneys.
Material and Methods: A total of 50 male albino rats were were divided into 5 groups:
Group 1: Control group.
Group 2: Type 2 diabetic rats.
Group 3: Type 2 diabetic nephropathy rats.
Group 4: Lisinopril-treated type 2 diabetic nephropathy rats. Group 5: Thiamine mononitrate-treated type 2 diabetic neph-ropathy rats.
Blood samples were collected for the measurements of fasting blood glucose, fasting blood insulin, blood urea, and blood albumin-creatinine ratio. Urine samples were collected for measurement of urinary albumin excretion. Systolic and diastolic blood pressure were measured. Nuclear factor kappa-B gene expression was estimated.
Results: Treatment with ACE inhibitors reduced fasting blood glucose, fasting blood insulin, blood urea, urinary albumin excretion, nuclear factor kappa B gene expression, systolic blood pressure and diastolic blood pressure. While treatment with thiamine mononitrate reduced fasting blood glucose, blood urea, urinary albumin excretion and systolic blood pressure.
Conclusion: The use of ACE inhibitors and thiamine in the treatment of kidney disease with type 2 diabetes significantly offered renal protection and improved the diabetic condition and may postpone the onset of renal injury in type 2 diabetic person.

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