Soluble Alpha Klotho Serum Level in Chronic Kidney Disease

Abstract
Background: Chronic Kidney Disease (CKD) is a world-wide public health problem which has bad side effects. Soluble alpha klotho is a phosphate and calcium regulatory hormone which can be used as a biomarker in diagnosis of chronic kidney disease.
Aim of Study: Evaluation of the level of soluble alpha klotho and its role in diagnosis of chronic kidney disease.
Patients and Method: The study was done on eighty cases that were divided into two categories according to their health status and estimated Glomerular Filtration Rate (eGFR), diseased group including sixty patients with chronic kidney disease (eGFR <120ml/min/1.73m2) and control group includ-ing twenty individuals (eGFR >120ml/min/1.73m2). Patients group were subdivided into five subgroups according to variation in their eGFR. All subjects were subjected to full history taking, thorough clinical examination and assessment of age, sex and risk factors for CKD as hypertension, diabetes mellitus and urinary tract infection. Routine laboratory tests included urea, creatinine, Ca, Po4 level and protein in urine. Serum soluble alpha klotho was estimated by Enzyme Linked Immunosorbent Assay (ELISA).
Results: Our study found that there was significant de-crease in soluble alpha klotho serum level with progression of chronic kidney disease which started to be more obvious in stage IIIB.
Conclusion: Soluble alpha klotho is a novel biomarker of chronic kidney disease that shows a significant decrease with disease progression and correlates with other mineral disorders of the disease, so it can be used in diagnosis of chronic kidney disease.