Comparative Clinical and Histological Study of Narrow Band UVB Phototherapy Versus Combined Narrow Band UVB Phototherapy and Microneedling in Treatment of Vitiligo
Dermatology & Leprosy Hospital, Ministry of Health* and The Department of Dermatology & Venereology** and Pathology***, Faculty of Medicine, Tanta University, Tanta, Egypt
Abstract Background: Vitiligo is an acquired pigmentary disorder of unknown etiology that affects up to 1% of the general population of all skin types. It is a multifactorial disorder. There are numerous medical and surgical treatments aimed at repigmentation. Microneedling is a minimally invasive procedure that uses fine needles to puncture the epidermis. The indications for microneedling therapy have grown significantly and it is becoming a widely used treatment in Dermatology. Aim of Study: To study the clinical and histological efficacy of combined NB-UVB phototherapy and microneedling versus NB-UVB phototherapy in the treatment of vitiligo. Patients and Methods: Twenty patients were divided into two Groups (A & B), each of 10 patients. Both groups were matched regarding age, sex, skin type and have a depigmented patch at the same corresponding site. Group A was subjected to microneedling with dermapen at one depigmented patch followed by NB-UVB phototherapy sessions twice weekly for three months. Group B was subjected to NB-UVB photo-therapy sessions twice weekly for three months. Two Skin biopsies one before and one after the therapy were taken for immunohistochemical examination by HMB 45. Results: The mean percentage of improvement was sig-nificantly high in Group A (48.50%±26.46) than Group B (20.0%±19.58). In Group A 20% showed mild improvement (G1), 20% showed moderate improvement (G2), (40%) showed good improvement (G3) and 20% showed excellent improve-ment (G4). In Group B 30% showed no improvement, 50% showed mild improvement (G1), 10% showed moderate improvement (G2) and 10% showed good improvement (G3). There was statistically significant difference between both groups (p=0.027*). Immunohistochemical changes revealed marked expression of HMB45 in Group A more than Group B, the mean of color intensity in Group A was 0.05±0.04 and a median of 0.03 while in Group B was 0.01±0.01. There was statistically significant difference between both groups (p=0.002*). Conclusion: Microneedling prior to NB-UVB photother-apy sessions was clearly superior to NB-UVB phototherapy alone with accelerating response. Microneedling is a tolerable procedure, safe with minimal side effects.
WAFAA M. RAMADAN, M.D., A. A. E. M., & NAEIM M. ABD EL-NABY, M.D., K. I. E. M. (2019). Comparative Clinical and Histological Study of Narrow Band UVB Phototherapy Versus Combined Narrow Band UVB Phototherapy and Microneedling in Treatment of Vitiligo. The Medical Journal of Cairo University, 87(June), 1439-1448. doi: 10.21608/mjcu.2019.53513
MLA
AMIRA A.A. EL-ZEFTAWY, M.Sc.; WAFAA M. RAMADAN, M.D.; KARIMA I. EL-DESOUKY, M.D.; NAEIM M. ABD EL-NABY, M.D.. "Comparative Clinical and Histological Study of Narrow Band UVB Phototherapy Versus Combined Narrow Band UVB Phototherapy and Microneedling in Treatment of Vitiligo", The Medical Journal of Cairo University, 87, June, 2019, 1439-1448. doi: 10.21608/mjcu.2019.53513
HARVARD
WAFAA M. RAMADAN, M.D., A. A. E. M., NAEIM M. ABD EL-NABY, M.D., K. I. E. M. (2019). 'Comparative Clinical and Histological Study of Narrow Band UVB Phototherapy Versus Combined Narrow Band UVB Phototherapy and Microneedling in Treatment of Vitiligo', The Medical Journal of Cairo University, 87(June), pp. 1439-1448. doi: 10.21608/mjcu.2019.53513
VANCOUVER
WAFAA M. RAMADAN, M.D., A. A. E. M., NAEIM M. ABD EL-NABY, M.D., K. I. E. M. Comparative Clinical and Histological Study of Narrow Band UVB Phototherapy Versus Combined Narrow Band UVB Phototherapy and Microneedling in Treatment of Vitiligo. The Medical Journal of Cairo University, 2019; 87(June): 1439-1448. doi: 10.21608/mjcu.2019.53513