Comparison of the Efficiencies of Ofloxacin Delivered in Different Forms (Conventional, Nanoemulsion and Nanoparticles) in the Treatment of Acute Diffuse Otitis Externa

Abstract
Background: Acute diffuse otitis externa is usually painful and annoying to the patient. It is an acute inflammation of the external auditory canal, auricle or both. Topical antibiotic preparations are the treatment of choice in uncomplicated cases. With the introduction of nanotechnology in the devel-opment of antibiotics, new horizons were opened up for the treatment of acute diffuse otitis externa.
Aim of Study: The objective of the present study is to compare the efficiencies of ofloxacin delivered in different forms (conventional, nanoemulsion and nanoparticles) in the treatment of acute diffuse otitis externa.
Patients and Methods: In the present study, we compared the efficiencies of ofloxacin delivered in different forms (conventional, nanoemulsion and nanoparticles) in cases with acute diffuse otitis externa. 40 patients with moderate degree of acute diffuse otitis externa were included in this study. The patients were classified into 4 groups, 10 patients in each group. A different form of ofloxacin was used in each group.
Results: The present study showed that: (1) There was no difference in cure rate between cases treated by nanoemul-sion form of ofloxacin and cases treated by nanoparticles form of ofloxacin. (2) Both of the nanoemulsion and nanopar-ticles are more effective than the conventional form (when used in the same concentration). (3) On trial of low concen-tration of the nanoemulsion form, no difference in cure rate from the conventional form was noted.
Conclusion: Nanopreparations of ofloxacin are more effective than the conventional form in management of cases of acute diffuse otitis externa.