Study of Serum Cyclophilin A Level in Patients with Acute Coronary Syndrome

Abstract
Background: Acute coronary syndrome (ACS) refers to a group of conditions due to diminished blood flow in the coronary arteries such that part of the heart muscle is incapable to act properly or dies.
Aim of Study: Is to evaluate the role of serum cyclophilin A level in acute coronary syndrome, its clinical significance in identifying patients with coronary artery disease and its correlation with the severity of the disease.
Methods: This study included 60 ACS cases, were sub-jected to full history taking. Clinical examination, Fasting blood glucose, Lipid profile (Total cholesterol, triglycerides, LDL and HDL), High sensitivity CRP, Troponin I level, CKMB level, Cyclophillin A. 20 apparently healthy age and sex matched subjects serving as a normal control group.
Results: Patients were divided into three groups unstable angina, NSTMI and STEMI. according to Cyclophilin A estimation: The mean values of serum Cyclophilin A level were significantly increased in unstable angina group, NSTMI group and STEMI group as compared to those in control group, there was also significant increase in NSTMI and STEMI as compared to those in group unstable angina.
Conclusion: From this study, it could be concluded that serum cyclophilin A levels Increased in patients with acute coronary syndrome and its associated with the progression of the disease suggesting its role in accelerating atheroscelerosis and may be a valuable marker for predicting the severity of ACS. So it is reasonable to assume that it could be a target for therapeutic treatment and its down regulation may be a new therapeutic strategy in ACS patients in near future.