Abstract Introduction: Endometrial cancer formed 0.004 of the tumors in Egypt. Detection of high grade tumors from the low-grade ones is mandatory for survival of the patients. Aim of the Work: The use of immunohistochemical tech-nique to detect the expression of Her-2 neu in endometrial carcinomas. Material and Methods: Fifty cases of endometrial carci-noma (37 endometrioid, 10 serous, 1 clear cell and 2 undif-ferentiated carcinomas) were stained with Her-2 neu and its immunoexpression results were evaluated statistically using Chi-square and t-test. Results: Her-2 neu was expressed in (76%) 38/50 cases with statistically significant relation between Her-2 expression and both grade of the tumor p<0.013 and stage p<0.05. Although Her-2 immunostaining was not correlated with tumor histological type p<0.088. Conclusions: Her-2 neu could be used to detect the low-grade, early-stages, endometrial carcinomas from the more aggressive high-grade endometrial carcinomas for therapy modulation.
NOHA ED. HASSAB ELNABY, M.D., A. T. E. M., & MOHAMED N. SALEM, M.D., A. A. A. M. (2018). Her-2 Neu Expression in Endometrial Carcinoma. The Medical Journal of Cairo University, 86(March), 69-76. doi: 10.21608/mjcu.2018.55033
MLA
AFAF T. ELNASHAR, M.D.; NOHA ED. HASSAB ELNABY, M.D.; ASMAA A. ABDELLATEF, M.D.; MOHAMED N. SALEM, M.D.. "Her-2 Neu Expression in Endometrial Carcinoma". The Medical Journal of Cairo University, 86, March, 2018, 69-76. doi: 10.21608/mjcu.2018.55033
HARVARD
NOHA ED. HASSAB ELNABY, M.D., A. T. E. M., MOHAMED N. SALEM, M.D., A. A. A. M. (2018). 'Her-2 Neu Expression in Endometrial Carcinoma', The Medical Journal of Cairo University, 86(March), pp. 69-76. doi: 10.21608/mjcu.2018.55033
VANCOUVER
NOHA ED. HASSAB ELNABY, M.D., A. T. E. M., MOHAMED N. SALEM, M.D., A. A. A. M. Her-2 Neu Expression in Endometrial Carcinoma. The Medical Journal of Cairo University, 2018; 86(March): 69-76. doi: 10.21608/mjcu.2018.55033