Fundus Fluorescein Angiography Versus Optical Coherence Tomography Angiography in Evaluation of Retinal Changes in Cases of Retinal Vein Occlusion

Abstract
Background: Retinal Vein Occlusion (RVO) is the second most common retinal vascular disease and the fifth common cause of visual loss worldwide. Fundus Fluorescein Angiog-raphy (FFA) is the gold standard investigation for its evaluation. However, it has some limitations. Optical Coherence Tomog-raphy Angiography (OCTA) is a novel technique for evaluation of retinal vascular changes. It may overcome some of the limitations of FFA.
Objective: Comparison between FFA and OCTA in eval-uation of retinal changes in retinal vein occlusion.
Methods: This prospective observational case series study was carried out on 30 eyes of 29 patients attending Ophthal-mology Outpatient Clinic in Tanta University Hospital from July 2016 to May 2017. FFA and OCTA were done to all patients at time of diagnosis. The results of both modalities were compared regarding macular ischemia, macular edema, microaneurysms, collaterals and neovascularizations.
Results: OCTA detected macular ischemia in the superficial plexus of 17 cases while it detected ischemia in the deep plexus of 25 cases. FFA detected macular ischemia in 9 cases and couldn't comment on ischemia in 5 cases. FFA detected macular edema in 23 cases while OCTA detected only 20 cases. Both collaterals and neovascularizations were detected in 3 separate cases by both OCTA and FFA. Microaneurysms were detected in 8 cases by FFA and in 4 cases by OCTA.
Conclusion: OCTA was superior to FFA in detection of macular ischemia. Both modalities were equal in detection of macular edema, collaterals and neovascularizations. FFA was superior in detection of microaneurysms.