The Value of Using Amantadine Upon Improving Conscious Level in Isolated Head Trauma Patients Guided by Glasgow Coma Scale and Bispectral Index

OMAR WAGIH, M.D., AHMED S. SAAD, M.Sc.;; HISHAM ABU ELDAHAB, M.D., INAS ELSHAZLY, M.D.;; OSMAN, M.D., SAFINAZ

doi:10.21608/mjcu.2018.56758

The Value of Using Amantadine Upon Improving Conscious Level in Isolated Head Trauma Patients Guided by Glasgow Coma Scale and Bispectral Index

Document Type : Original Article

Authors

The Department ofAnaesthesiology, Faculty of Medicine, Cairo University

10.21608/mjcu.2018.56758

Abstract

Abstract Background: We performed the current study to find out the effect of Amantadine upon rate of improvement of con-scious level in patients with isolated head injuries undergoing surgical intervention.
Aim of the Study: Finding out the value of using Amanta-dine upon improving of consciousness in head trauma patients.
Patients and Methods: Patients in group 1 (n=20) were given amantadine intraoperative at a dose of 100mg IV infusion over 3 hours, then amantadine were given at a dose of 100mg IV infusion over 3 hours every 12 hours for 7 days then was switched to tablet form at a dose of 300mg per day divided into 3 equal doses, the 1st was given in the morning and the last before 5 o'clock PM.
Patients in group 2 (n=20) were given placebo instead at the same form and intervals.
Glasgow coma scale and bispectral index readings were recorded at time of arrival, immediate post operative, 3 days and 2 weeks post operative. Results: We found that Glasgow coma scale rate of im-provement in group 1 was 4.53±2.61 and in group 2 was 2.11 ±2.81 which is statistically significant p-value 0.014.
Conclusion: We conclude from this study that the rate of improvement of patients given amantadine was significantly higher than those given placebo.

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