Abstract Background: Renal cell carcinoma (RCC) is considered the commonest and most fatal malignant neoplasm of the kidney. Distant metastases are found in 30% of RCC patients at diagnosis, which is considered an important sign of predic-tion of patients' prognosis. So trying to clarify molecular mechanisms of metastases in RCC could help to discover a recent therapeutic target to decrease and control distant metastases and subsequently might improve patients prognosis. Aim of the Study: Was to assess the EZH2 & Twist-1 combined expressions in RCC tissues with different histopatho-logical subtypes and to correlate their expression with clin-icopathological parameters. Material and Methods: We have assessed expression of EZH2 & Twist-1 in tissue by using immunohistochemistry in 50 paraffin blocks of RCC different histopathological subtypes, analyzed correlations between the levels of combined expres-sions and clinicopthological data. Results: Increased EZH2 expression was positively asso-ciated with advanced AJCC stage, Lymph Node (L.N) metas-tases (p=0.006), higher grade (p<0.001), and presence of distant metastases (p=0.045). Increased Twist-1 expression was positively associated with higher grade, L.N (p<0.001) & distant metastases (p=0.04) and AJCC stage (p=0.01). Both EZH& Twist-1 expressions were positively correlated to each other (p<0.001). Conclusion: EZH2 & Twist-1 are considered markers of poor prognosis in RCC and so they could be used as novel therapeutic targets in RCC patients.
DINA A. KHAIRY, M.D., A. S. M. M. (2018). Clinicopathological Significances of EZH2 & Twist-1 Combined Expressions in Renal Cell Carcinoma (RCC). The Medical Journal of Cairo University, 86(June), 2019-2028. doi: 10.21608/mjcu.2018.56936
MLA
ABLA S. MAHMOUD, M.D.; DINA A. KHAIRY, M.D.. "Clinicopathological Significances of EZH2 & Twist-1 Combined Expressions in Renal Cell Carcinoma (RCC)". The Medical Journal of Cairo University, 86, June, 2018, 2019-2028. doi: 10.21608/mjcu.2018.56936
HARVARD
DINA A. KHAIRY, M.D., A. S. M. M. (2018). 'Clinicopathological Significances of EZH2 & Twist-1 Combined Expressions in Renal Cell Carcinoma (RCC)', The Medical Journal of Cairo University, 86(June), pp. 2019-2028. doi: 10.21608/mjcu.2018.56936
VANCOUVER
DINA A. KHAIRY, M.D., A. S. M. M. Clinicopathological Significances of EZH2 & Twist-1 Combined Expressions in Renal Cell Carcinoma (RCC). The Medical Journal of Cairo University, 2018; 86(June): 2019-2028. doi: 10.21608/mjcu.2018.56936