Predictors of Infection and Mortality in Living Donor Liver Transplantation

Abstract Background: Infection is the most frequent cause of morbidity and mortality following liver transplantation in Egypt.
Aim of the Study: This study was directed at assessing the frequency of infection occurring in the early postoperative period and the possible associated preoperative, operative, and postoperative predictors of infection and mortality in patients underwent living related liver transplantation at National Liver Institute.
Patients and Methods: This was prospective cohort hos-pital based study described rate of infections occurring in the early postoperative period and their predictors as well as predictors of mortality. It was carried out on 40 living donor liver transplantation patients' who provided informed consent to participate. Participants were interviewed to gather predictor factors data using multiple question model previously prepared questionnaire, biophysiologic measures and observation checklist. Results: Living donor liver transplantation complicated Infection was 68.8% in which 59.1% of infection episodes occurred in the first month post transplantation and the incidence declined thereafter. High infection rate was associ-ated with prolonged operative time (14.8±3.07). Infection induced mortality was 77.8%.
Conclusion: Most of infection episodes induced mortality occurred in the first month post liver transplantation due to bad selection of donors which were associated with risk factors of infection and predictors of mortality. Recommendations: Careful evaluation of donor and re-cipient prior to liver transplantation prevents serious post transplantation infection, either by excluding risky donors or by defining the need for specific antimicrobial therapy post liver transplantation.