Urinary Cyclophilin: A New Marker for Diabetic Nephropathy

Abstract
Background: Nephropathy is a significant cause of mor-bidity and mortality in patients with Diabetes Mellitus (DM). The condition is characterized by persistent albuminuria and may be decline in the Glomerular Filtration Rate (GFR). Urinary cyclophillin A has been proposed as a simple, accurate and rapid endogenous marker for DN.
Aim of Study: To assess the value of urinary cyclophillin A anew marker of diabetic nephropathy.
Subjects and Methods: Group I: 60 patients with type 2 diabetes mellitus which will be subdivided into: (A) 30 diabetic patients with diabetic nephropathy. (B) 30 diabetic patients without diabetic nephropathy. Group II: 30 healthy persons as a control group.
Results: There was significance association between urinary cyclophillin A and serum creatinine, blood urea, 24 h protein collection and ACR.
Urinary cyclophilin A found higher in diabetic nephropathy patients than diabetic patients without nephropathy so it is a new marker for diabetic nephropathy.
Conclusion: The results of this study suggest that urinary cyclophillin A new marker for diabetic nephropathy.