Evaluation of Brain Volume Loss in Different Clinical Types of Multiple Sclerosis Patients

Abstract
Background: Brain atrophy is an important imaging biomarker in predicting future disability and progression of disease in multiple sclerosis.
Aim of Study: We need to evaluate brain volume loss in different clinical types of MS and correlates it with physical disability using NeuroQuaqnt 2.0 automated volumetric meas-urement of brain atrophy in MS.
Material and Methods: We conducted the following study on 40 MS patients (4 CIS, 8 PPMS, 22 RRMS and 6 SPMS) for clinical evaluation, assessment their physical disability by (EDSS) and automated volumetric measurement of 3 parameters (whole brain, lateral ventricles and thalami vol-umes) by obtain 3D T1 non contrast, saggital MRI scan by using new software (NeuroQuant®2.0 automated volumetric measurement of brain atrophy) of MS patients.
Results: Thalami atrophy was predominant atrophy in 24 patients. Also, it was predominant atrophy in different clinical types (2 CIS, 4 PPMS, 12 RRMS and 6 SPMS) patients. Morphometry results were correlated with physical disability (whole brain volume r=–0.400, p=0.026), (thalami volume r=–0.379, p=0.016), and (lateral ventricles volume r=0.365, p=0.044). MS patients with (disease duration >1 year) had significant lower whole brain volume (p=0.037), lower thalami volume (p=0.019) and higher lateral ventricles volumes (p=0.044).
Conclusion: Thalami atrophy is a predominant atrophy in different clinical types of MS patients. Thalami atrophy may be used a sole indices in brain atrophy measuring. Brain atrophy correlates with physical disability and progress with duration of illness.