Abstract Background: Thyroid dysfunction may occur in women in menopausal period or after ovariectomy. Effect of exercise on thyroid function remains controversial and need more investigations. Aim of Study: This study was done to investigate the effect of chronic regular swimming exercise on thyroid function in ovariectomized rats. Material and Methods: Rats were divided into 6 groups (7 rats per each); Sham-operated sedentary (sham-S) group, (2) Sham-operated with swimming exercise training (sham + Ex) group, (3) Ovariectomized sedentary (OVX-S) group, (4) OVX-group with swimming exercise training (OVX + Ex), (5) OVX-group injected with 17-b estradiol (OVX + E), (6) OVX-group with swimming exercise training and injected with 17-R estradiol (OVX + Ex + E). 3 months after the surgery, rats were exposed to the exercise protocol for another 3 months. BMI was calculated. At the end experimental period, the serum levels of T3, T4, TSH, estradiol and interleukin-6 (IL-6) were determined. The thyroid glands were weighed. The histopathological examination of thyroid tissue was done for determination of epithelial cell height, follicular and colloidal areas. Results: In OVX-S group, final BMI was significantly increased, serum levels of T3 and T4 were significantly decreased with significant increase of serum TSH level as compared with Sham-S group. While, as compared to OVX-S group, final BMI was significantly decreased, T3 and T4 levels were significantly increased with decrease of TSH level in OVX-treated groups. Estradiol level was significantly decreased in OVX-S group compared to sham-S group. While, in comparison with OVX-S group, its level significantly increased in OVX-treated groups. Serum IL-6 was insignificant changed between Sham-S, OVX-S and OVX + E groups. But, it significantly increased in Sham-Ex, OVX + Ex and OVX + Ex + E groups as compared to Sham-S, OVX-S and OVX + E groups. Histopathological examination showed significant decrease of the thyroid gland weight and height of epithelial cells, with significant increase in the follicular and colloidal areas in the OVX-S group as compared to sham-S group. These histopathological changes were improved in OVX-treated groups. Conclusion: We concluded that regular swimming exercise in OVX-rats ameliorated the thyroid hypofunction which may be related to its ability to increase estradiol level in these rats.
NERMIN M. MADI, M.D., M. H. E. M., & METWALI, M.D., H. E. (2018). Effect of Chronic Regular Swimming Exercise on Thyroid Function in Ovariectomized Rats. The Medical Journal of Cairo University, 86(December), 3397-3406. doi: 10.21608/mjcu.2018.60312
MLA
MERVAT H. EL-SAKA, M.D.; NERMIN M. MADI, M.D.; HALA E. METWALI, M.D.. "Effect of Chronic Regular Swimming Exercise on Thyroid Function in Ovariectomized Rats". The Medical Journal of Cairo University, 86, December, 2018, 3397-3406. doi: 10.21608/mjcu.2018.60312
HARVARD
NERMIN M. MADI, M.D., M. H. E. M., METWALI, M.D., H. E. (2018). 'Effect of Chronic Regular Swimming Exercise on Thyroid Function in Ovariectomized Rats', The Medical Journal of Cairo University, 86(December), pp. 3397-3406. doi: 10.21608/mjcu.2018.60312
VANCOUVER
NERMIN M. MADI, M.D., M. H. E. M., METWALI, M.D., H. E. Effect of Chronic Regular Swimming Exercise on Thyroid Function in Ovariectomized Rats. The Medical Journal of Cairo University, 2018; 86(December): 3397-3406. doi: 10.21608/mjcu.2018.60312