The Precise Local Tumor Characteristics of Supraglottic Carcinoma: A Comparison between Clinical, Radiological and Pathological Findings

Abstract
Background: In most cases of supraglottic cancer the tumor has already involved more than one sub site including a broad surface of mucosa with asymmetric extension in both surface and depth. In order to achieve proper loco-regional control of supraglottic cancer while at the same time providing the best possible results regarding organ preservation, knowl-edge of accurate tumor extension is necessary. This is achieved by thorough clinical, radiological and post-operative patho-logical assessment.
Aim of the Study: Determine the accurate extension of supraglottic squamous cell carcinoma by whole organ section-ing and comparing it with radiological and endoscopic findings.
Material and Methods: This study included 36 patients suffering from Laryngeal carcinoma originating from the supraglottic larynx. Direct laryngoscopy was done for all patients under general anesthesia for detailed primary tumor assessment. Detailed radiological assessmentusing C.T with contrast was done. Detailed histopathological examination by whole organ sectioning was done for the laryngectomy specimen.
Results: Radiological assessment was superior to clinical assessment in detection of tumor extension. On comparing radiological and pathological assessment the percentage increase of invasion of the paraglottic space and strap muscles were the only variables that were statistically significant (p-value=0.025, 0.001 respectively). On comparing clinical and pathological assessment base of tongue, vallecula and pyriform sinus were found to increase significantly statistically by pathological assessment (p-values=0.025, 0.046, 0.046 respec-tively).