Abstract Background: Study of brain metabolites using 1 HMRS in children with cerebral palsy. Aim of Work: To study the metabolite changes in the basal ganglia of children with CP in comparison with a normal control group of the same age by using proton magnetic resonance spectroscopy (1HMRS). Material and Methods: Thirty children with different types of CP with associated developmental delay were exam-ined. Different types of CP were included (spastic, dyskinetic, dystonic or choreo-athetoid and ataxic CP). The control group consisted of twenty normally developing children. The relative concentrations of N-acetylaspartate (NAA), choline (Cho), myo-inositol (mI), creatine (Cr) and their combinations within 1 cm3 brain multi voxels were measured. Results: Children with CP showed reduced ratios of NAA: Cr, NAA: Cho, mI: Cr in the basal ganglia and the increased ratio of NAA: mI and CHO: CR in relation to that of the control group. There was age-dependency increase in NAA: Cr and NAA: Cho in the basal ganglia. Metabolites ratio differs according to the severity of CP. Conclusion: MRS plays a promising role in evaluating children with cerebral palsy and also in determining the degree of learning disability aiming at a better rehabilitation of children with CP.
NOHA M. ABD EL-MABOUD, M.D., R. S. A. M., & ZAKREYA AL-SHAHAWY, M.D., A. (2018). The Role of Magnetic Resonance Imaging in the Evaluation of Children with Cerebral Palsy: A Proton Magnetic Resonance Spectroscopy Study. The Medical Journal of Cairo University, 86(December), 3833-3838. doi: 10.21608/mjcu.2018.61852
MLA
RANIA S. ABOUKHADRAH, M.D.; NOHA M. ABD EL-MABOUD, M.D.; AL-SHYMAA ZAKREYA AL-SHAHAWY, M.D.. "The Role of Magnetic Resonance Imaging in the Evaluation of Children with Cerebral Palsy: A Proton Magnetic Resonance Spectroscopy Study". The Medical Journal of Cairo University, 86, December, 2018, 3833-3838. doi: 10.21608/mjcu.2018.61852
HARVARD
NOHA M. ABD EL-MABOUD, M.D., R. S. A. M., ZAKREYA AL-SHAHAWY, M.D., A. (2018). 'The Role of Magnetic Resonance Imaging in the Evaluation of Children with Cerebral Palsy: A Proton Magnetic Resonance Spectroscopy Study', The Medical Journal of Cairo University, 86(December), pp. 3833-3838. doi: 10.21608/mjcu.2018.61852
VANCOUVER
NOHA M. ABD EL-MABOUD, M.D., R. S. A. M., ZAKREYA AL-SHAHAWY, M.D., A. The Role of Magnetic Resonance Imaging in the Evaluation of Children with Cerebral Palsy: A Proton Magnetic Resonance Spectroscopy Study. The Medical Journal of Cairo University, 2018; 86(December): 3833-3838. doi: 10.21608/mjcu.2018.61852