The Predictive Effect of Mean Platelet Volume (MPV) and Neutrophil-to-Lymphocyte Ratio (NLR) on the Functional Outcome of Acute Ischemic Stroke

Abstract
Background: Inflammation has been reported to constitute a major component of ischemic stroke pathology. Nevertheless, to the best of our knowledge, no previous studies have inves-tigated the NLR and MPV values in the cases of stroke stratified by subtype.
Aim of Study: The aim of our study is to predict the role MPV and NLR in short-term outcome in patients with ischemic stroke and their association to stroke severity, stroke risk factors and functional outcome.
Patients and Methods: This prospective cross sectional study directed on 125 patients with first time acute ischemic stroke. All members exposed to full history taking, detailed clinical examination and neurological checking. Brain imaging was performed after hospital admission. Blood tests were drawn for appraisal of the mean platelet volume (MPV) (in FL) and the neutrophil-lymphocyte ratio (NLR).
Results: Our results revealed that the mean value for NLR was higher in dead patients with ischemic stroke. By ROC curve, higher NLR at admission predicted the mortality than MPV. We found higher NLR levels in patients with more severe stroke. However, We did not observe a significant correlation between the MPV, the stroke severity, and outcome.
Conclusion: NLR was an independent risk factor and serves as a sensitive index for the prognosis of ACI patients. Further well-designed and large-scale prospective studies are necessary to evaluate platelet MPV and NLR for observing patients with cerebral infarction among different territories of Egypt and for stroke subtypes.