Interplay between Exercise and SIRT1 in Skeletal Muscle of Diabetic Male Rats

Document Type : Original Article

Authors

The Departments of Medical Physiology* and Biochemistry**, Faculty of Medicine, Cairo University

Abstract

Abstract
Background: Great evidences support the promising effect of physical exercise on pathophysiological changes associating diabetes. Several molecular mechanisms of the beneficial outcome of physical training have been suggested. The role of silent information regulator one (SIRT 1) in diabetes after exercise training is still obscure.
Aim of Study: To evaluate wheather re-establishing SIRT 1 activity after exercise training can improve diabetic outcome or not.
Patients and Methods: Forty male Wistar albino rats (n=10 per group) were randomized to control, diabetic (STZ; 60mg/kg i.p.), diabetes + exercise (D+EX) and exercise + diabetes (EX+D) (swimming 1h/day, 5days/week before diabetes). After the end of the study, body mass index (BMI), serum glucose, triglyceride, HDL, SIRT1 expression and activity were measured.
Results: Both exercised groups showed significant decrease in serum glucose and triglycerides, significant increase in serum HDL, SIRT1level and activity and insignificant change in BMI compared with control group. There was no significant difference between exercised groups, approaching to normal levels in EX+D group. Correlation studies showed SIRT1 level and activity negatively correlated with glucose and TG levels, positively correlated with HDL level among all groups.
Conclusion: Exercise training before or after diabetes improved glycemic control and lipid profile, SIRT upregulation may have a role in this improvement.

Keywords

The Medical Journal of Cairo University
Volume 87, September
September 2019
Pages 3573-3579

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