Cytochrome 2J2 (CYP2J2) Gene Polymorphism in Coronary Artery Disease

Document Type : Original Article

Authors

The Departments of Clinical Pathology* and Cardiology**, Faculty of Medicine, Ain Shams University, Egypt

Abstract

Abstract
Background: Coronary artery disease is a multifactorial disease where genetic risk factors are targeted by the environ-mental risk factors leads to disease pathogenesis. CYP2J2 is a monooxygenase which metabolize arachidonic acid into cardioprotective compounds. Genetic polymorphisms in CYP2J2 are common especially CYP2J2*7 (rs890293) which reduce CYP2J2 gene expression and subsequently its cardio-protective effects.
Aim of Study: The aim of the present case control study to investigate the relation between CYP2J2*7 (G-50T) (rs890293) gene polymorphism and coronary artery disease (CAD) susceptibility and severity in a cohort of Egyptian individuals.
Patients and Methods: The study was conducted on 50 CAD patients and 50 age and sex-matched apparently healthy individuals. Assay of CYP2J2*7 gene SNP (rs890293) was performed by PCR amplification and Restriction Fragment Length Polymorphism (PCR-RFLP) technique.
Results: Our results revealed that the genotypic and allelic frequencies of G-50T didn't show any statistically significant association neither with the susceptibility of coronary artery disease or with the number of significantly diseased coronaries. Also no statistically significant difference between GG gen-otypes patients and GT genotypes patients as regard risk factors for CAD.
Conclusions: There was no significant association between CYP2J2*7 gene polymorphism (G-50T) (rs890293) and risk of coronary artery disease and also no association between this gene polymorphism and the severity of CAD in the sample of Egyptian population included in this study.

Keywords

The Medical Journal of Cairo University
Volume 87, September
September 2019
Pages 3961-3968

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