Abstract Background: Cancer associated fibroblasts (CAFs) are main components of tumor microenvirnoment. They act an essential role in tumor progression, invasion and unrespon-siveness to chemotherapy. Aim of Study: This work aims to study the relation of CAFs with hepatocellular carcinoma (HCC) developement and progression. Material and Methods: This is an uncontrolled retrospec-tive study carried upon 30 cases of HCC. Cases were collected from archives of Pathology Department and Early Cancer Detection Unit (ECDU), Faculty of Medicine, Benha Univer-sity, and from International Medical Center during the years 2010-2015. Podoplanin (D2-40), alpha smooth muscle actin (a-SMA) and CD31 immunohistochemichal staining were performed and evaluated for each case. Results: Both D2-40 and a-SMA showed different distri-butions and levels of expression. D2-40 positivity was localized to the peri-tumoral area, while a-SMA was detected in both intra- and peritumoral areas. Expression of both markers was not statistically related to each other (p>0.05). D2-40 was positive in 73.3% of casesand a-SMA showed high expres-sionin 60% of cases. Both positive D2-40 and high a-SMA showed positive relations to tumor grade (p
RASHA M. ABDRABUH, M.D., G. A. A. E. M., & G. ROSHDY, M.D., R. (2019). Evaluation of Cancer-Associated Fibroblasts Markers in Hepatocellular Carcinoma. The Medical Journal of Cairo University, 87(December), 4337-4343. doi: 10.21608/mjcu.2019.77440
MLA
GHADA A. ABD EL-FATTAH, M.D.; RASHA M. ABDRABUH, M.D.; RANIA G. ROSHDY, M.D.. "Evaluation of Cancer-Associated Fibroblasts Markers in Hepatocellular Carcinoma". The Medical Journal of Cairo University, 87, December, 2019, 4337-4343. doi: 10.21608/mjcu.2019.77440
HARVARD
RASHA M. ABDRABUH, M.D., G. A. A. E. M., G. ROSHDY, M.D., R. (2019). 'Evaluation of Cancer-Associated Fibroblasts Markers in Hepatocellular Carcinoma', The Medical Journal of Cairo University, 87(December), pp. 4337-4343. doi: 10.21608/mjcu.2019.77440
VANCOUVER
RASHA M. ABDRABUH, M.D., G. A. A. E. M., G. ROSHDY, M.D., R. Evaluation of Cancer-Associated Fibroblasts Markers in Hepatocellular Carcinoma. The Medical Journal of Cairo University, 2019; 87(December): 4337-4343. doi: 10.21608/mjcu.2019.77440