The Departments of Hepatology Gastroenterology & Infectious Diseases*, Clinical & Chemical Pathology** and Internal Medicine***, Faculty of Medicine, Benha University, Egypt
Abstract Background: Serotonin known to be a neurotransmitter can regulate several key aspects of liver biology. Aim of Study: This study aimed to determine the role of serum serotonin levels (5-HT) as a non-invasive marker in the prediction of esophageal and fundal varices in cirrhotic patients. Patients and Methods: The study included seventy cirrhotic patients with hepatitis C virus and fifteen apparently healthy subjects as a control group. Patients were further sub-classified according to upper Gastrointestinal Endoscopy into three groups: Group A: Included 30 cirrhotic patients without esophageal varices (OV), Group B: Included 29 cirrhotic patients with OV, Group C: Included 11 cirrhotic patients with OV and fundal varices. All subjects were subjected to full history taking, clinical evaluation, routine laboratory investigations and serum-serotonin by ELISA. Results: The mean level of serum Serotonin showed a gradual increase in cirrhotic patients with the highest level in oesophageal and fundal varices (94.04±8.51ng/ml), followed by patients with oesophagal varices only (39.2±18.38ng/ml), and both groups were significantly increased than the patient group with no oesophageal varices. There was a positive correlation between serum serotonin level and serum creatinine level, presence and grading of oesophagal varices and the presence of fundal varices. Serum serotonin level at a cutoff value 32.2ng/ml had a sensitivity of 72% and a specificity of 60% in prediction of OV in cirrhotic patients but at cutoff level 28.4ng/ml had low sensitivity (55%) and bad specificity (25%) in discrimination between grads of OV, while serum serotonin level at a cutoff value 79. 1ng/ml had a sensitivity of 100% and a specificity of 96.6% to diagnose patients with oesophagal and fundal varices. Applying multivariate analysis, serum serotonin level was an independent predictor for oesophagal varices. Conclusion: Serum serotonin levels could be used as a serum non-invasive marker for the presence of gastro-oesophageal varices, but it could not discriminate between the grades of oesophageal varices.
EMAN G. BEHIRY, M.D., M. Z. O. M., & MOHAMED, M.D., M. A. (2019). Diagnostic Significance of Serum Serotonin Levels in Prediction of Esophageal and Fundal Varices in Cirrhotic Patients. The Medical Journal of Cairo University, 87(December), 4413-4419. doi: 10.21608/mjcu.2019.78259
MLA
MAHA Z. OMAR, M.D.; EMAN G. BEHIRY, M.D.; MOHAMED A. MOHAMED, M.D.. "Diagnostic Significance of Serum Serotonin Levels in Prediction of Esophageal and Fundal Varices in Cirrhotic Patients", The Medical Journal of Cairo University, 87, December, 2019, 4413-4419. doi: 10.21608/mjcu.2019.78259
HARVARD
EMAN G. BEHIRY, M.D., M. Z. O. M., MOHAMED, M.D., M. A. (2019). 'Diagnostic Significance of Serum Serotonin Levels in Prediction of Esophageal and Fundal Varices in Cirrhotic Patients', The Medical Journal of Cairo University, 87(December), pp. 4413-4419. doi: 10.21608/mjcu.2019.78259
VANCOUVER
EMAN G. BEHIRY, M.D., M. Z. O. M., MOHAMED, M.D., M. A. Diagnostic Significance of Serum Serotonin Levels in Prediction of Esophageal and Fundal Varices in Cirrhotic Patients. The Medical Journal of Cairo University, 2019; 87(December): 4413-4419. doi: 10.21608/mjcu.2019.78259