Abstract Background: Social Isolation (SI) which means absence or insufficient contact with others is a key factor in psychiatric disorders development, which might be necessary for effective psychological treatment as social rehabilitation. Social expe-rience during the infantile period affects brain function and behaviour in rodents, dogs and human. Aim of Study: The current study was designed to elucidate the neuroprotective role of MT on experimentally-induced SI on CA1of rat hippocampus and frontal cortex. Material and Methods: Twenty adult albino rats were divided into four groups, control, sham control, SI and SI + MT. The Body Weight (BW), Brain Weight (BrW) were determined. Brain sections were subjected to histological, morphometric, biochemical and statistical studies. Results: SI induced various histological changes in both hippocampus and frontal cortex in the form of degeneration and absent neurons. SI also caused a significant (sig) increase in area % of caspase 3 and TNF Immunoexpression (IE) were recorded. Sig decrease in the activity of Total Antioxidant Capacity (TAC), Brain Derived Neurotropic Factor (BDNF), Superoxide Dismutase (SOD) activity, Acetyle Choline Este-rase (ACHE), dopamine level as well ARC gene, and a sig increase in Malondialdehyde (MDA) levels, FOS gene, sero-tonin and AB-42. Concomitant administration with MT im-proved sig the previously mentioned changes. Conclusion: SI might lead to various neurological degen-erations as indicated by the histological, morphometric, biochemical changes. These changes were ameliorated by concomitant administration with MT.
E.M. HAMOUD, M.D., A. (2019). Ameliorative Role of Melatonin on CA1 of Hippocampus and Frontal Cortex in Induced Social Isolation in Adult Male Albino Rat. The Medical Journal of Cairo University, 87(December), 5163-5172. doi: 10.21608/mjcu.2019.88810
MLA
AMANY E.M. HAMOUD, M.D.. "Ameliorative Role of Melatonin on CA1 of Hippocampus and Frontal Cortex in Induced Social Isolation in Adult Male Albino Rat". The Medical Journal of Cairo University, 87, December, 2019, 5163-5172. doi: 10.21608/mjcu.2019.88810
HARVARD
E.M. HAMOUD, M.D., A. (2019). 'Ameliorative Role of Melatonin on CA1 of Hippocampus and Frontal Cortex in Induced Social Isolation in Adult Male Albino Rat', The Medical Journal of Cairo University, 87(December), pp. 5163-5172. doi: 10.21608/mjcu.2019.88810
VANCOUVER
E.M. HAMOUD, M.D., A. Ameliorative Role of Melatonin on CA1 of Hippocampus and Frontal Cortex in Induced Social Isolation in Adult Male Albino Rat. The Medical Journal of Cairo University, 2019; 87(December): 5163-5172. doi: 10.21608/mjcu.2019.88810