Abstract Background: TBI (Traumatic Brain Injury) is a worldwide leading cause of death and disability. Liver cirrhosis is known as a significant risk factor for increased morbidity and mortality in trauma patients. HCV (Hepatitis C Virus) is a major cause of liver cirrhosis worldwide especially in Egypt which has the highest HCV prevalence all over the world. Aim of Study: Evaluate impact of HCV on outcome of moderate and severe TBI patients. Methods: Prospective cohort study with stratified random sample of 120 patients of moderate and severe TBI admitted in Kasr Al-Ainy hospitals in the period between February 2016 and January 2017. Screening for HCV antibodies with ELISA technique was done to detect HCV +ve patients. Assessment of case deterioration after admission, resurger, length of ICU (Intensive care unit) stay, ventilator days, mortality and GOS (Glasgow outcome score) was done. Results: Out of the 120 patients included; 11 patients were HCV +ve, while 109 patients were found negative for HCV antibody. Overall mortality was 28/120 patients. Mortality among HCV +ve patients was 7/11 patients compared with the HCV –ve patients: 21/109 patients (p=0.003). Length of ICU stay in HCV +ve patients: 8.73±4.78 days and in HCV –ve patients: 9.39±9.52 days (p=0.422). Ventilator days in HCV +ve patients were 8.69±4.12 and in HCV –ve patients: 12.51±12.31 days. Conclusion: TBI in HCV +ve patients is associated with significantly increased mortality rates and lower GOS com-pared with HCV–ve patients, which agrees with published literature in this subject. Other significant prognostic indicators were age and GCS on admission.
TAHER M. ALI, M.Sc., M. F. A. A. M., & M. ALI, M.D., A. (2020). Outcome of Moderate and Severe Traumatic Brain Injury in Hepatitis C Virus Patients. The Medical Journal of Cairo University, 88(March), 445-451. doi: 10.21608/mjcu.2020.94010
MLA
MOHAMMED F. ADEL ALI, M.D.; TAHER M. ALI, M.Sc.; AHMED M. ALI, M.D.. "Outcome of Moderate and Severe Traumatic Brain Injury in Hepatitis C Virus Patients". The Medical Journal of Cairo University, 88, March, 2020, 445-451. doi: 10.21608/mjcu.2020.94010
HARVARD
TAHER M. ALI, M.Sc., M. F. A. A. M., M. ALI, M.D., A. (2020). 'Outcome of Moderate and Severe Traumatic Brain Injury in Hepatitis C Virus Patients', The Medical Journal of Cairo University, 88(March), pp. 445-451. doi: 10.21608/mjcu.2020.94010
VANCOUVER
TAHER M. ALI, M.Sc., M. F. A. A. M., M. ALI, M.D., A. Outcome of Moderate and Severe Traumatic Brain Injury in Hepatitis C Virus Patients. The Medical Journal of Cairo University, 2020; 88(March): 445-451. doi: 10.21608/mjcu.2020.94010