The Predictive Value of Combining Leach Sign and Serum Progesterone in Diagnosis of Undisturbed Ectopic Pregnancy

Abstract
Background: Ectopic Pregnancy is a dangerous compli-cation of early gestation. In low-income nations it is considered one of the chief causes of maternal mortality. The majority of mortalities occur briefly after hospital admission making ectopic pregnancy a prominent public health issue.
Patients and Methods: The current research study was a prospective observational in fashion conducted in the fetal Medicine Department at Ain Shams University Maternity Hospital and involved 100 cases consecutively admitted with clinical symptoms and signs indicative of an ectopic pregnancy.
Results: Cases with Leash sign had ststistically significant lower progesterone level and more frequent ectopic pregnancy. (p-values <0.001). Ectopic pregnancy cases had statistically significant lower progesterone serum level and more frequent leash sign. (p-values <0.001). There was statistical significant high agreement level between existence of Leash sign and ectopic pregnancy diagnosis. (p-value <0.001, 95% CI=0.945l eash sign, true negative=75.0%, false negative=0.0%, true positive =23.0%, false positive=2%.
Conclusion: Leash sign is a highly sensitive sonographic sign that could be implemented on widespread practice how-ever other sonographic markers should be respected in inte-gration with bio markers since there is no single sign or marker that could be applicable in all case scienarios.